Wednesday, July 24, 2019
Biochemistry and Medicine Information in Pharmacology Assignment
Biochemistry and Medicine Information in Pharmacology - Assignment Example AD brains are particularly marked by neurofibrillary tangles, amyloid plagues, neuronal cell loss, innate immune responses as well as a prominent activation of the glial cells. This paper critically investigates the potential relationship between Alzheimerââ¬â¢s disease, Beta-C kinins and brain-derived neurotrophic factor (BDNF) as well as their improvement on the cognitive function of patients. Numerous recent empirical studies suggest that the production of a class of brain-derived neurotrophic factor (BDNF) is significantly diminished among the patients suffering from Alzheimerââ¬â¢s disease. Generally, BDNF is normally produced in the entorhinal cortex area of the brain (the part involved with cognition and memory) throughout an individualââ¬â¢s life Honea et al., 2013). It is widely believed that the production of the brain-derived neurotrophic factor is particularly enhanced by beta-C kinins, a class of neuropharmacological molecules some of which include AB 123. Although the correlation between the lowered levels of BDNF and Alzheimerââ¬â¢s disease (AD) has not been effectively established, studies indicate that neurotrophic factors normally play a critical protective role against amyloid beta toxicity (Mattson, 2008, p.97). This is further supported by the growing number of scientific studies in Alzheimerââ¬â¢s disease that have revealed significant alterations in the immune responses including observable changes in the macrophage and lymphocyte distribution and activation. In a recent study conducted by Weinstein et al(2014), the researchers examined the levels of BDNF in 2131 healthy adults and then followed them for ten years. The results revealed that up to 50% individuals with the highest baseline levels of BDNF were less likely to develop dementia compared to their counterparts with the lowest levels of the molecule. It was concluded that a higher level of BDNF may protect against the occurrence of memory loss.
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